Millions of people across the globe struggle with depression, a debilitating mental disorder. Depression has been a gigantic challenge for medical professionals and researchers. Traditional treatments, such as antidepressants and psychotherapy have been effective, but not for everyone. Lately, a novel treatment called Spravato (generic name: Esketamine) has proven to be a potential breakthrough in depression management, especially treatment-resistant depression. Breakthru Psychiatric Solutions offers the FDA-approved Spravato Sandy Springs for managing treatment-resistant depression. Let’s gain an insight into Spravoto’s how it works and its potential impact on the field of psychiatry.Development and ApprovalSpravato was developed by Janssen Pharmaceuticals. In 2019, it got approval from the U.S. FDA, as a nasal spray for treating treatment-resistant depression in adults. How is Spravoto unique?Spravato is derived from Ketamine, which is a famous sedative and recreational drug. Ketamine displays rapid antidepressant effects but there are concerns about its potential for addiction and side effects. Spravato is specifically formulated as Esketamine, the S-enantiomer of ketamine. It functions as a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, which leads to increased synaptic plasticity and neurotransmitter release, particularly glutamate. This unique mechanism of action sets Spravato apart from conventional antidepressants that predominantly target serotonin, norepinephrine, and dopamine receptors. AloofnessDizzinessNauseaIncreased blood pressure
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